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2 edition of role of tumour necrosis factor-[alpha] in an animal model of Kawasaki disease. found in the catalog.

role of tumour necrosis factor-[alpha] in an animal model of Kawasaki disease.

Joyce Siu-Wah Hui-Yuen

role of tumour necrosis factor-[alpha] in an animal model of Kawasaki disease.

by Joyce Siu-Wah Hui-Yuen

  • 321 Want to read
  • 38 Currently reading

Published .
Written in English


About the Edition

Kawasaki disease (KD) is the most common cause of multisystem vasculitis in childhood. Its propensity for aneurysm formation makes KD quite unique among coronary artery diseases, and the leading cause of pediatric acquired heart disease in the developed world. Tumour necrosis factor-alpha (TNFalpha) is a pleiotropic inflammatory cytokine elevated during the acute phase of KD. In a murine model of KD, rapid TNFalpha production occurs in the peripheral immune system after disease induction. This immune response becomes site-directed, with migration to coronary arteries dependent on TNFalpha mediated events. Production of TNFalpha in the heart is coincident with the presence of inflammatory infiltrate at the coronary arteries, which persists during aneurysm development. Ablation of TNFalpha effector functions abrogated inflammation and elastin breakdown in coronary vessels, rendering mice resistant to coronary arteritis and aneurysm formation. Thus, TNFalpha is necessary for development of coronary artery lesions in an animal model of Kawasaki disease.

The Physical Object
Pagination112 leaves.
Number of Pages112
ID Numbers
Open LibraryOL20239061M
ISBN 100494025301

The objective of this study was to evaluate the effect of tumour necrosis factor‐alpha inhibitors (TNF‐αI) on Alzheimer's disease‐associated pathology. Design A literature search of PubMed, Embase, PsychINFO, Web of Science, Scopus, and the Cochrane Library databases for human and animal studies that evaluated the use of TNF‐αI was. We have demonstrated recently the pivotal role of tumour necrosis factor (TNF)-alpha-mediated matrix metalloproteinase (MMP)-9 activity in the pathogenesis of elastin breakdown in a murine model.

Tumour necrosis factor‐alpha has been reported to play a role in neuropathic pain. Leung and Cahill [ ] described the role of TNF‐α in neuropathic pain. Neuropathic pain is pathological pain where nociceptive responses persist beyond the resolution of damage to the nerve or its surrounding tissue. Evaluation of Tumor necrosis factor-alpha in patients with Coronary Artery Disease 53 |Page incubated. After washing away the unbounded enzyme labelled antibody, the bound conjugate is detected by adding freshly prepared tetramethylbenzidine (TMB) substrate.

  The prevalence of rheumatoid arthritis (RA) is relatively constant in many populations, at –%. However, a high prevalence of RA has been reported in the Pima Indians (%) and in the Chippewa Indians (%). In contrast, low occurrences have been reported in populations from China and Japan. These data support a genetic role in disease risk. Kawasaki disease (KD) is an acute, self-limited, systemic vasculitis with predilection for coronary artery involvement and the most common cause of acquired heart disease in children from developed countries [1•].KD affects mostly young children.


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Role of tumour necrosis factor-[alpha] in an animal model of Kawasaki disease by Joyce Siu-Wah Hui-Yuen Download PDF EPUB FB2

We have demonstrated recently the pivotal role of tumour necrosis factor (TNF)-alpha-mediated matrix metalloproteinase (MMP)-9 activity in the pathogenesis of elastin breakdown in a murine model of KD, Lactobacillus casei cell wall extract-induced coronary by: Tumor Necrosis Factor Alpha.

TNF is a pleiotropic regulatory cytokine produced by several cell types, including in adipose tissue, that can exert a variety of effects on cellular and biological processes, including immunity, inflammation, apoptosis, angiogenesis, coagulation, growth promotion and inhibition, and energy homeostasis.

Tumor necrosis factor alfa is naturally produced by activated macrophages and monocytes and has pleiotropic effects on normal and malignant cells. Unfortunately, the systemic administration of tumor necrosis factor alfa as a single agent gave disappointing results with severe adverse effects and no significant clinical antitumor effect [1, 2.

We correlated the development of lung injury in viable motheaten mice with tumor necrosis factor-alpha (TNF-alpha) levels in serum and lung. Significantly increased serum TNF-alpha levels were observed by enzyme-linked immunosorbent assay in viable motheaten mice at 4, 6, and 10 weeks of age as compared with normal control littermate by: This review details tumor necrosis factor alpha (TNF) biology and its role in sleep, and describes how TNF medications influence sleep/wake activity.

Substantial evidence from healthy young animals indicates acute enhancement or inhibition of endogenous. Mice have been extensively employed as an animal model of renal damage caused by Shiga toxins. In this study, we examined the role of the proinflammatory cytokine tumor necrosis factor alpha (TNF-)inthe development of toxin-mediated renal disease in mice.

Mice pretreated with. Why TNF-Alpha Is Important in IBD. TNF is an important topic for treating inflammatory bowel disease (IBD).

TNF is found in higher amounts in people with Crohn's disease than it is people who do not have Crohn's disease. TNF is also found, to a lesser degree, in the stool of people who have ulcerative e of this association, it's thought that TNF plays a role in the development.

Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine that exerts both homeostatic and pathophysiological roles in the central nervous pathological conditions, microglia release large amounts of TNF-α; this de novo production of TNF-α is an important component of the so-called neuroinflammatory response that is associated with several neurological disorders.

The proinflammatory cytokine tumour necrosis factor alpha (TNFα) was shown to play a striking role for the regulation of this balance in the gut. Depending on the cellular conditions, on the one hand TNFα is able to mediate cell survival by activating NFκB signalling.

Tumour necrosis factor (TNF), also called cachectin, a naturally occurring protein that is produced in the human body by the phagocytic cells known as macrophages. (The latter can engulf and destroy bacteria, viruses, and other foreign substances.)TNF is produced by macrophages when they encounter the poisonous substance in bacteria that is known as endotoxin.

Tumor necrosis factor‐alpha (TNF‐α) is recognized as a cytokine because of its involvement in inflammation‐mediated biological defense functions.

Although TNF‐α is primarily produced by macrophages, it is also produced by other cells, including lymphocytes, Kupffer cells, natural killer cells and adipocytes. 4. Selmaj K, Raine CS. Tumour necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann Neurol. ; 5. Sharief MK, Hentges R.

Association between tumor necrosis factor-alpha and disease progression in patients with multiple sclerosis. N Engl J Med.

; 6. Selmaj K, Raine CS, Farooq M, Norton WT. tumour formation, intestinal homeostasis has to be tightly controlled and therefore a strict balance between cell death and proliferation has to be maintained. The proinflammatory cytokine tumour necrosis factor alpha (TNF) was shown to play a striking role.

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein involved in systemic inflammation and is one of the cytokines that make up the acute phase is produced chiefly by activated macrophages, although it can be produced by many other cell types such as T helper cells, natural killer cells, neutrophils.

A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory is involved in autoimmune and immune-mediated disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa and refractory asthma, so TNF inhibitors may be used in their.

O’Connor JJ. Targeting tumour necrosis factor-α in hypoxia and synaptic signalling. Ir J Med Sci. ;(2)– [59] Park KM, Bowers WJ. Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction.

Cellular Signalling. ;22(7)– [60] Stellwagen D, Beattie EC, Seo JY, Malenka RC. Cachexia is an independent prognostic marker of survival in many chronic diseases including heart failure and malaria.

Morbidity and mortality from malaria is high in most of the third world where it presents a very challenging public health problem. Malaria may present in the UK as fever in the returning traveller or as fever in overseas visitors.

This was a single-centre study to evaluate the usefulness of tumour necrosis factor-α (TNF-α) blocker, infliximab (IFX), for treatment of Kawasaki disease (KD) in children in Northern Indian. play an immunoregulatory role in lupus-prone animals (Table 1).

However, this role is not at all uniform, and TNF has different consequences depending upon the strain and the stage of the disease. Tumor necrosis factor can ameliorate murine lupus InJacob and McDevitt [9] reported that NZB/W mice showed diminished production of TNF, a. The pathological process occurring in cells that are dying from irreparable injuries.

It is caused by the progressive, uncontrolled action of | Explore the latest full-text research PDFs. Tumour necrosis factor‐alpha has been reported to play a role in neuropathic pain. Leung and Cahill described the role of TNF‐α in neuropathic pain.

Neuropathic pain is pathological pain where nociceptive responses persist beyond the resolution of damage to the nerve or its surrounding tissue. Central sensitization, increased sensitivity in spinal cord dorsal horn neurons after injuries, plays an essential role in the induction and maintenance of chronic pain.

However, synaptic mechanisms underlying central sensitization are incompletely known. Growing evidence suggests that proinflammatory cytokines (PICs), such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis.Tumor Necrosis Factor. Tumour necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine produced by many cell types (blood monocytes, macrophages, mast cells and endothelial cells), and plays multiple complex functional roles within the immune system, including the stimulation of inflammation, cytotoxicity, the regulation of cell adhesion and the induction of cachexia [1].